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Investigative Ophthalmology & Visual Science, Vol 26, 481-485, Copyright © 1985 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Effect of LTD4 on conjunctival vasopermeability and blood-aqueous barrier integrity

DF Woodward and SE Ledgard

The effect of leukotriene D4 (LTD4) on the microvascular permeability of selected ocular tissues of the guinea pig was evaluated quantitatively by utilizing 125I-albumin and 51Cr-erythrocytes. Topically applied LTD4 (1 ng-10 micrograms) produced a dose-related increase in conjunctival microvascular permeability. However, topical administration of such doses of LTD4 did not promote albumin leakage into the aqueous humor or iris-ciliary body. Intravitreal injection of graded doses of LTD4 also failed to increase the albumin content of the aqueous humor and iris-ciliary body. Thus, although LTD4 increased conjunctival microvascular permeability, it does not appear to disrupt the blood-aqueous barrier of the guinea pig eye.


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