IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Grogan, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Grogan, J. B.

Investigative Ophthalmology & Visual Science, Vol 26, 501-510, Copyright © 1985 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Antigen nonspecific rejection of allogeneic skin implants in the anterior chamber of sensitized rats

JB Grogan

As expected, skin implants placed in the anterior chamber of the eye of rats systemically sensitized with alloantigen from the antigen specific (second party) donor implants are rapidly rejected, indicating that the anterior chamber offers no barrier to the efferent immune response. However, during our studies it was noted that antigen nonspecific (third party) skin implants placed in the anterior chamber of the eye of similarly sensitized rats were also rejected in accelerated fashion. In all of the donor-recipient rat strain combinations tested which were sensitized by orthotopic skin grafts, third party skin implants placed in the anterior chamber of the eye were rejected within 14 days. A similar rejection pattern was noted in the anterior chamber of rats that were sensitized by the foot pad injection of graded doses of RT1 incompatible spleen cells. Rats sensitized with mouse skin grafts also rejected RT1 histoincompatible allogeneic implants within the anterior chamber, a result not noted in rats sensitized with either dog, rabbit, or pig skin grafts.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the Association for Research in Vision and Ophthalmology