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Investigative Ophthalmology & Visual Science, Vol 26, 571-574, Copyright © 1985 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Immunology of corneal allograft rejection: HLA-DR antigens on human corneal cells

E Young, WJ Stark and RA Prendergast

Human stromal and endothelial cultures were established from corneas obtained from the Maryland Eye Bank. Cultures were incubated in the presence of human gamma interferon for 4 days, trypsinized, washed, and then stained with a monoclonal reagent specific for human Class II (HLA- DR) antigens. Under these conditions, 100% of human corneal endothelial cells and 40 to 70% human corneal stromal cells expressed HLA-DR antigens.


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