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Investigative Ophthalmology & Visual Science, Vol 26, 992-1001, Copyright © 1985 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Synaptic lamellae of the photoreceptors of pearl and wild-type mice

MA Williams, J Gherson, LJ Fisher and LH Pinto

The retina of the pearl mutant mouse, C57BL/6J pe/pe, exhibits reduced light sensitivity in the dark-adapted condition (Balkema and Pinto, J Neurophysiol 48:968, 1982). The authors searched for an anatomic correlate in the retina which could relate to the functional deficit. Electron microscopic mosaics of the outer plexiform layer of light- and dark-adapted pearl and wild-type mice were analyzed. The numerical density and length of the photoreceptor synaptic lamellae showed these parameters to be indistinguishable in wild-type and pearl retinas under conditions of both light- and dark-adaptation. Light-adapted pearl retinas exhibited some rod spherules that contained structurally modified synaptic lamellae with bulbous thickenings and adjacent electron-dense bodies. These lamellar modifications were neither apparent in the light-adapted, wild-type retinas, nor in the dark- adapted retinas of either genotype. Pronase application to ultrathin sections hydrolyzed synaptic lamellae, bulbous thickenings and electron dense bodies.


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M. A. Adly, I. Spiwoks-Becker, and L. Vollrath
Ultrastructural Changes of Photoreceptor Synaptic Ribbons in Relation to Time of Day and Illumination
Invest. Ophthalmol. Vis. Sci., September 1, 1999; 40(10): 2165 - 2172.
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