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Investigative Ophthalmology & Visual Science, Vol 26, 1223-1229, Copyright © 1985 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Ocular inflammation in autoimmune MRL/Mp mice

DA Jabs, EL Alexander and WR Green

Congenic mice of the MRL/Mp strain spontaneously develop an autoimmune connective tissue disease that shares immunologic and histopathologic features with the human disorders systemic lupus erythematosus, rheumatoid arthritis, and systemic vasculitis. The autoimmune disorder in these mice is markedly accelerated by the recessive gene lpr. Older MRL/Mp-lpr/lpr mice develop significant inflammatory ocular disease, including choroiditis, scleritis, and orbital vasculitis. Animals of both the MRL/Mp-+/+ and MRL/Mp-lpr/lpr substrains develop lacrimal gland inflammatory infiltrates. The MRL/Mp mouse provides a potential model for ocular inflammatory disease and for Sjogren's syndrome.


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D. A. Jabs, H. C. Gerard, Y. Wei, A. L. Campbell, A. P. Hudson, E. K. Akpek, B. Lee, R. A. Prendergast, and J. A. Whittum-Hudson
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E. K. Akpek, D. A. Jabs, H. C. Gerard, R. A. Prendergast, A. P. Hudson, B. Lee, and J. A. Whittum-Hudson
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D. A. Jabs, R. A. Prendergast, E. M. Rorer, A. P. Hudson, and J. A. Whittum-Hudson
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D. A. Jabs, B. Lee, J. Whittum-Hudson, and R. A. Prendergast
The Role of Fas-Fas Ligand-Mediated Apoptosis in Autoimmune Lacrimal Gland Disease in MRL/MpJ Mice
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D. A. Jabs, B. Lee, J. A. Whittum–Hudson, and R. A. Prendergast
Th1 Versus Th2 Immune Responses in Autoimmune Lacrimal Gland Disease in MRL/Mp Mice
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