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Investigative Ophthalmology & Visual Science, Vol 26, 1252-1256, Copyright © 1985 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

In vitro enhancement of anterior chamber GVH reactions

AA Khodadoust, M Farazdaghi, AM Silverstein and RA Prendergast

The injection of sensitized allogeneic lymphocytes into the anterior chamber of the rabbit eye results in a local graft-verus-host reaction, with focal destruction of the corneal endothelium. This experimental model permits in vitro manipulation of effector cells, and the study of the mechanisms involved in corneal graft rejection. The authors now show that the in vitro activation of sensitized lymphocytes is a one- way mixed lymphocyte reaction yields "supersensitized" effector cells which are quantitatively enriched and qualitatively altered to yield more severe and more rapid endothelial target cell destruction.




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Copyright © 1985 by the Association for Research in Vision and Ophthalmology