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Investigative Ophthalmology & Visual Science, Vol 26, 1299-1303, Copyright © 1985 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Iontophoresis of epinephrine isomers to rabbit eyes induced HSV-1 ocular shedding

JM Hill, Y Shimomura, BS Kwon and Sr Gangarosa LP

Iontophoresis of 0.01% levo(-) epinephrine for 8 min at 0.8 mAmp once daily for 3 consecutive days induces ocular shedding of herpes simplex virus type 1 (HSV-1) in latently infected rabbits. In the present experiment, we tested dextro(+) and levo(-) epinephrine for their comparative effects on induced HSV-1 ocular shedding. One hundred percent of the eyes shed virus after either 0.01% dextro(+) or levo(-) epinephrine iontophoresis (8 min, 0.8 mAmp). However, the shedding frequency caused by 0.005% levo(-) epinephrine was significantly higher (P less than 0.05) than that by 0.005% dextro(+) epinephrine when the iontophoresis was conducted at 0.4 mAmp for 4 min. Iontophoresis of 0.001% levo(-) epinephrine for 8 min at 0.8 mAmp once daily for 3 consecutive days and iontophoresis of 0.001% dextro(+) epinephrine for 8 min at 0.8 mAmp once daily for 3 consecutive days did not induce HSV- 1 ocular shedding in latently infected rabbits. The data suggest that the mechanism of induction of HSV-1 ocular shedding by epinephrine is correlated to the receptor potency of levo(-) epinephrine.


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X. Zheng, M. E. Marquart, J. M. Loustch, P. Shah, B. Sainz, A. Ray, R. J. O’Callaghan, H. E. Kaufman, and J. M. Hill
HSV-1 Migration in Latently Infected and Naive Rabbits after Penetrating Keratoplasty
Invest. Ophthalmol. Vis. Sci., October 1, 1999; 40(11): 2490 - 2497.
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