IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Isenberg, S. J.
Right arrow Articles by Jedrzynski, M. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Isenberg, S. J.
Right arrow Articles by Jedrzynski, M. S.

Investigative Ophthalmology & Visual Science, Vol 27, 1512-1515, Copyright © 1986 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Conjunctival hypoxia in diabetes mellitus

SJ Isenberg, WE McRee and MS Jedrzynski

A frequently cited theory for the pathogenesis of neovascularization in diabetic retinopathy is that retinal hypoxia and/or ischemia release a factor which stimulates neovascularization. To the authors' knowledge, there is no direct in vivo evidence in the human proving this theory. One hundred and twenty-two diabetic subjects were studied to see whether worsening retinopathy was associated with changes in conjunctival oxygen tension (pO2). Diabetics without retinopathy had a conjunctival pO2 which was similar to an age-matched normal population. Diabetics with only background retinopathy had a significantly lower conjunctival pO2 than those without retinopathy (P less than 0.01). Diabetics with proliferative retinopathy showed a conjunctival pO2 that was significantly lower than either of the first two groups (P less than 0.05). The lowest value of all was found in patients with rubeosis iridis. Duration of diabetes alone did not correlate significantly to conjunctival pO2. These findings support the hypoxic theory of diabetic neovascular retinopathy.


This article has been cited by other articles:


Home page
 IOVSHome page
S. H. Hardarson, A. Harris, R. A. Karlsson, G. H. Halldorsson, L. Kagemann, E. Rechtman, G. M. Zoega, T. Eysteinsson, J. A. Benediktsson, A. Thorsteinsson, et al.
Automatic Retinal Oximetry
Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 5011 - 5016.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the Association for Research in Vision and Ophthalmology