IOVS Journal of Cell Biology
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Investigative Ophthalmology & Visual Science, Vol 27, 1757-1760, Copyright © 1986 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Potentiation of collagen synthesis in explants of the rabbit eye by 5 beta-dihydrocortisol

AL Southren, MR Hernandez, D l'Hommedieu, GG Gordon and BI Weinstein

The biologic effect of 5 beta-dihydrocortisol on collagen synthesis was evaluated. The metabolite was found to potentiate subthreshold levels of dexamethasone in increasing 3H-proline incorporation in cells of the outflow region of the rabbit. Digestion of the tissue with highly purified collagenase indicated that the 3H-proline was incorporated into collagen type protein. This study demonstrates another biologic activity of 5 beta-dihydrocortisol, a metabolite found to accumulate in cells cultured from trabeculectomy specimens from patients with primary open angle glaucoma.




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Copyright © 1986 by the Association for Research in Vision and Ophthalmology