IOVS Journal of Virology
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Investigative Ophthalmology & Visual Science, Vol 27, 1767-1770, Copyright © 1986 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Permeability of the isolated dog retinal pigment epithelium to carboxyfluorescein

S Tsuboi and JE Pederson

Outward (retina to choroid) and inward (choroid to retina) permeabilities of carboxyfluorescein and fluorescein in the isolated dog retinal pigment epithelium (RPE)-choroid were determined. Outward permeability was 9 and 47 times larger than inward permeability for carboxyfluorescein and fluorescein, respectively. The outward permeability of carboxyfluorescein was seven times lower than that of fluorescein, whereas there was no statistical difference between the inward permeabilities. Carboxyfluorescein is thus distinguished from fluorescein by its low affinity to the outwardly directed organic anion transport system. 10(-4) M probenecid caused greater than 98% inhibition of the outward transport of 6 X 10(-5) M carboxyfluorescein and 6 X 10(-6) M fluorescein.




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Copyright © 1986 by the Association for Research in Vision and Ophthalmology