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Investigative Ophthalmology & Visual Science, Vol 27, 264-268, Copyright © 1986 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Rhodopsin phosphorylation in developing normal and degenerative mouse retinas

TA Shuster and DB Farber

The developmental pattern of rhodopsin phosphorylation in degenerative (rdle homozygote) and normal (rd/+ heterozygote) mouse retina has been investigated. The results indicate that rhodopsin levels are comparable in the 2 retinas up to about 10 days of age but that rhodopsin phosphorylation is not. The phosphorylation of rhodopsin is substantially reduced in the degenerative retina during development. This abnormality may be an expression of the rd lesion. The rhodopsin kinase/phosphatase system, the G protein, and the visual pigment are all involved in the modulation of cGMP-phosphodiesterase activity in normal retinas. A defect in any of these components could account for the reduced level of cGMP-phosphodiesterase activity in rd retinas, resulting in cGMP accumulation and subsequent photoreceptor degeneration.


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T. S. Rex, R. N. Fariss, G. P. Lewis, K. A. Linberg, I. Sokal, and S. K. Fisher
A Survey of Molecular Expression by Photoreceptors after Experimental Retinal Detachment
Invest. Ophthalmol. Vis. Sci., April 1, 2002; 43(4): 1234 - 1247.
[Abstract] [Full Text] [PDF]


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Copyright © 1986 by the Association for Research in Vision and Ophthalmology