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Investigative Ophthalmology & Visual Science, Vol 27, 356-363, Copyright © 1986 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Cellular immune function of patients with retinitis pigmentosa

RL Hendricks and GA Fishman

Although initial investigations of peripheral blood lymphocytes (PBL) from patients with retinitis pigmentosa (RP) demonstrated a reduced percentage of Leu-4 positive (pan-T) lymphocytes, the authors recently determined that the absolute number of Leu-4 positive cells per milliliter of blood is normal. This investigation studied the production of the lymphokines gamma-interferon (gamma-IFN) and interleukin-2 (IL-2) in cultures of concanavalin-A stimulated PBL. The difference in the mean production of gamma-IFN or IL-2 by PBL from 33 RP patients versus PBL from 16 controls did not achieve statistical significance at P less than 0.05. Overall, the data did not demonstrate significant cellular immune abnormalities in patients with RP.




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Copyright © 1986 by the Association for Research in Vision and Ophthalmology