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Investigative Ophthalmology & Visual Science, Vol 27, 443-446, Copyright © 1986 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Covalent changes in MIP26K during aging of the human lens membrane

L Takemoto, M Takehana and J Horwitz

Rabbit antisera have been made to the C-terminal octapeptide of bovine MIP26K (residues 256-263) and to an octapeptide near the C-terminus (residues 252-259). Use of these antisera in Western blot analysis of membrane from young vs old human lenses, and from cortex vs nucleus of old human lenses, suggest age-related covalent changes in the C- terminus of MIP26K. These age-related changes in anti-256-263 and anti- 252-259 sera can be mimicked by treatment of lens membrane with carboxypeptidase Y, suggesting the loss of 1-8 amino acid residues from the C-terminus of the 26,000 dalton form of MIP26K during aging of the normal human lens.




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Copyright © 1986 by the Association for Research in Vision and Ophthalmology