IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weinreb, R. N.
Right arrow Articles by Alvarado, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weinreb, R. N.
Right arrow Articles by Alvarado, J.

Investigative Ophthalmology & Visual Science, Vol 27, 525-531, Copyright © 1986 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Subconjunctival injections. Preservative-related changes in the corneal endothelium

RN Weinreb, I Wood, L Tomazzoli and J Alvarado

The morphologic effects on rabbit corneal endothelium of several common ophthalmic vehicle constituents were examined following subconjunctival administration. Profound dose-dependent changes consisting of intercellular vacuolization and thickening of the endothelial layer were noted within 1 day following administration of solutions that contained sodium bisulfite or methylparaben and propylparaben. These changes persisted for at least 5 days except in those eyes treated with the lowest concentration of sodium bisulfite. In contrast, administration of sodium citrate and creatinine or unpreserved normal saline resulted in only minimal effects. These changes are of concern because these agents are present in many preparations used to treat a wide variety of eye diseases.


This article has been cited by other articles:


Home page
 Arch OphthalmolHome page
N. J. Anderson, W. D. Woods, T. Kim, D. E. Rudnick, and H. F. Edelhauser
Intracameral Anesthesia: In Vitro Iris and Corneal Uptake and Washout of 1% Lidocaine Hydrochloride
Arch Ophthalmol, February 1, 1999; 117(2): 225 - 232.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the Association for Research in Vision and Ophthalmology