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Investigative Ophthalmology & Visual Science, Vol 27, 831-836, Copyright © 1986 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

A monoclonal antibody that binds to cones

V Lemmon

A monoclonal antibody that binds to cones has been produced. This antibody, 50-1B11, binds to the outer segments of cones in rhesus monkeys. Immunohistochemical experiments indicate that 50-1B11 binds to a subset of photoreceptors, probably cones, in all vertebrate species tested thus far, including man. In vitro experiments on chicken retina indicate that the antigen is intracellular and associated with the plasma membrane, while electronmicroscopic-immunohistochemical studies demonstrate that the antigen is contained in the lamellae of the outer segments of rhesus cones.




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Copyright © 1986 by the Association for Research in Vision and Ophthalmology