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Investigative Ophthalmology & Visual Science, Vol 27, 1296-1300, Copyright © 1986 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein

I Gery, B Wiggert, TM Redmond, T Kuwabara, MA Crawford, BP Vistica and GJ Chader

Rats immunized with microgram amounts of interphotoreceptor retinoid- binding protein (IRBP), a glycoprotein which localizes specifically in the eye and pineal gland, developed uveoretinitis and pinealitis. The severity and onset of changes were found to be dose-related and to be enhanced by B. pertussis bacteria. In general, the inflammatory changes induced by IRBP resembled those provoked by S-antigen (S-Ag), but significant differences were noted between the two diseases. The possible usefulness of the new experimental autoimmune disease is discussed.




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Copyright © 1986 by the Association for Research in Vision and Ophthalmology