IOVS Genetics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tsuchiya, M.
Right arrow Articles by Mizuno, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsuchiya, M.
Right arrow Articles by Mizuno, K.

Investigative Ophthalmology & Visual Science, Vol 28, 822-825, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Affinity of ocular acid-insoluble melanin for drugs in vitro

M Tsuchiya, S Hayasaka and K Mizuno

The authors examined spectrophotometrically the ability of drugs to bind with ocular acid-insoluble melanin. Each drug, at 5 X 10(-5) M, was incubated at 37 degrees C for 8 hr with 4 mg of melanin in 20 mM potassium phosphate buffer (pH 7.4 and 8.0) or in 20 mM acetate buffer (pH 4.8). The authors findings showed that chloroquine, thioridazine, befunolol, pindolol, daunomycin, and 5-fluorouracil bound to melanin (pH 4.8, 7.4, and 8.0). Methotrexate bound to melanin (pH 4.8 but not at 7.4 and 8.0). Pilocarpine, epinephrine, acyclovir, vincristine, and colchicine did not bind to ocular acid-insoluble melanin.


This article has been cited by other articles:


Home page
 IOVSHome page
L. Pitkanen, V.-P. Ranta, H. Moilanen, and A. Urtti
Permeability of Retinal Pigment Epithelium: Effects of Permeant Molecular Weight and Lipophilicity
Invest. Ophthalmol. Vis. Sci., February 1, 2005; 46(2): 641 - 646.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
W. W. Lai, V. D. Bhavnani, H. H. Tessler, and D. P. Edward
Effect of Melanin on Traumatic Hyphema in Rabbits
Arch Ophthalmol, June 1, 1999; 117(6): 789 - 793.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1987 by the Association for Research in Vision and Ophthalmology