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Investigative Ophthalmology & Visual Science, Vol 28, 874-880, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

In vitro and in vivo susceptibility of Candida keratitis to topical polyenes

DM O'Day, WA Ray, RD Robinson, WS Head and AM Savage

The susceptibility of Candida albicans to topical amphotericin B and natamycin was evaluated in a model of stromal keratitis in Dutch-belted rabbits and compared with minimal inhibitory concentrations in vitro. Treatment was delayed 24 hr to allow invasive disease to occur and was then continued for 5 days. Ten strains of Candida albicans comprised the test panel. For amphotericin B, the minimal inhibitory concentration (MIC) by tube dilution classified the same strains as resistant or susceptible as did the in vivo response. A dose-response was observed with different concentrations of the drug. For natamycin, the MIC misclassified two strains. The rate of administration of natamycin required in this model was much higher than for amphotericin B, a therapeutic effect being observed with natamycin only when the drug was administered every 30 min during the in vivo efficacy and in vitro susceptibility with these strains is in agreement with that observed in the authors' previous studies using a model of immediate treatment.


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D. M. O’Day, W. S. Head, C. Csank, D. J. Shetlar, R. D. Robinson, G. W. McCollum, R. Yang, T. L. Zhu, and M. X. Wang
Differences in Virulence between Two Candida albicans Strains in Experimental Keratitis
Invest. Ophthalmol. Vis. Sci., April 1, 2000; 41(5): 1116 - 1121.
[Abstract] [Full Text]


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Copyright © 1987 by the Association for Research in Vision and Ophthalmology