IOVS Journal of Cell Biology
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Investigative Ophthalmology & Visual Science, Vol 28, 886-892, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Role of oxygen radicals in experimental allergic uveitis

NA Rao, A Sevanian, MA Fernandez, JL Romero, JP Faure, Y de Kozak, GO Till and GE Marak Jr

The experimental autoimmune disease elicited by a large dose of retinal S antigen in guinea pigs is characterized by massive necrotizing uveitis and retinitis. Treatment of these animals with the antioxidants superoxide dismutase, catalase, and sodium benzoate resulted in marked reduction of uveal inflammation. The attenuated inflammation was characterized by a relatively well-preserved retina and retinal pigment epithelium along with a reduction of subretinal exudate and vitreous inflammation. These findings suggest that reactive oxygen metabolites may play a role in the destruction of ocular tissue and amplification of the inflammatory process in experimental uveitis.




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Copyright © 1987 by the Association for Research in Vision and Ophthalmology