IOVS Journal of Virology
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Investigative Ophthalmology & Visual Science, Vol 28, 1022-1024, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Uveoscleral outflow: diffusion or flow?

JE Pederson and CB Toris

Shallow peripheral ciliochoroidal detachments with 10(-4) M fluorescein isothiocyanate dextran 70 were created in cynomolgus monkey eyes. Anterior chamber fluorophotometric readings were taken for 6 hr. From the anterior chamber fluorescence values, the rate of tracer movement from the supraciliary space into the anterior chamber was calculated. The rate of movement was 0.003 microliter/min, expressed in equivalent volumes of tracer solution. This value is more than 200 times lower than the rate of tracer movement from the anterior chamber to the supraciliary space. It is concluded that tracer movement from the anterior chamber to the supraciliary space (uveoscleral route) results from fluid flow rather than diffusion.


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J. D. Lindsey and R. N. Weinreb
Identification of the Mouse Uveoscleral Outflow Pathway Using Fluorescent Dextran
Invest. Ophthalmol. Vis. Sci., July 1, 2002; 43(7): 2201 - 2205.
[Abstract] [Full Text] [PDF]


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Copyright © 1987 by the Association for Research in Vision and Ophthalmology