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Investigative Ophthalmology & Visual Science, Vol 28, 1024-1027, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Steroid potentiation of beta-adrenergic-sensitive adenylate cyclase in rabbit ciliary processes

MA Harris and B Schwartz

Dexamethasone (3.3 X 10(-8) M) potentiated 1-isoproterenol-stimulated adenylated cyclase activity in vitro in rabbit ciliary process epithelial membrane preparations. The ka for isoproterenol stimulation of the cyclase was 5 X 10(-7) M in control membranes, 2.5 X 10(-9) M in membranes preincubated with dexamethasone, and 6 X 10(-8) M with corticosterone. No change was observed in basal adenylate cyclase activity. Changes in enzyme activity at maximally stimulating levels of isoproterenol were not consistently different. Dose response to corticosterone in the presence of 10(-7) M 1-isoproterenol shows maximum effect at 6.6 X 10(-8) M corticosterone.




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Copyright © 1987 by the Association for Research in Vision and Ophthalmology