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Investigative Ophthalmology & Visual Science, Vol 28, 1030-1032, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Tubocurarine chloride inhibits rod outer segment shedding in the frog retina

WC Gordon and ME Keith

The cholinergic postsynaptic neuromuscular blocker, tubocurarine chloride (curare), attenuates the rod shedding response of the frog in a dose-dependent manner. Injections of curare into the dorsal lymph sacs or intraocularly into the vitreous of the eye produced similar results. Intraocular injections of Ringer solution of varying quantities of 0.9% NaCl (the carrier solution of the commercially prepared curare), had no adverse effect on the shedding response. Additionally, injections of curare into one eye had no effect on the rod shedding rate of the other eye.




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Copyright © 1987 by the Association for Research in Vision and Ophthalmology