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Investigative Ophthalmology & Visual Science, Vol 28, 927-933, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Reinnervation of primate ciliary muscle following ciliary ganglionectomy [published erratum appears in Invest Ophthalmol Vis Sci 1987 Aug;28(8):1235]

KA Erickson-Lamy and PL Kaufman

Ciliary ganglionectomy and/or postganglionic ciliary neurectomy in the cynomolgus monkey was followed by supersensitivity to intramuscular (i.m.) pilocarpine and lack of response to topical eserine and to electrical stimulation of the Edinger-Westphal nucleus. Normal responsiveness to pilocarpine and eserine returned in most instances after about 6 months. An accommodative response to stimulus of the Edinger-Westphal nucleus was also present and, as in control eyes, could be blocked by hexamethonium. Collectively, these findings demonstrate that parasympathetic innervation to the ciliary muscle mediating accommodation traverses a typical peripheral autonomic synapse, almost certainly located predominantly in the ciliary ganglion; by 6 months after denervation, the ciliary muscles have reinnervated; and the parasympathetic pathway to the eye exhibits plasticity and capacity for regeneration.




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Copyright © 1987 by the Association for Research in Vision and Ophthalmology