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Investigative Ophthalmology & Visual Science, Vol 28, 1043-1048, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Genetic regulation of light damage to photoreceptors

MM LaVail, GM Gorrin, MA Repaci, LA Thomas and HM Ginsberg

Albino mice of different inbred strains have been exposed to constant fluorescent lighting at an illuminance level of 115-130 ft-c for intervals of 1-6 weeks. Under these conditions the photoreceptors in retinas of albino BALB/cByJ mice rapidly degenerate, whereas the photoreceptors in retinas of albino C57BL/6J-c2J mice are remarkably more resistant to light damage. F1 heterozygotes produced from these two strains display an intermediate degree of light-induced degeneration. These findings demonstrate that phenotypically identical populations with different genetic constitutions can show markedly different sensitivities to light, and that genetic factors must now be included as a determinant for the severity of light damage.


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