IOVS Circulation
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Investigative Ophthalmology & Visual Science, Vol 28, 1049-1058, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Nomarski evaluation of rod outer segment renewal in a hereditary retinal degeneration. Comparison with autoradiographic evaluation

G Aguirre and L Andrews

Differential interference contrast (Nomarski) optics and autoradiography were used to estimate independently the rate of outer segment renewal in the early stages of progressive rod-cone degeneration (PRCD) in dogs. We have found that significant reductions in renewal rate are demonstrable using the two methods of analysis: autoradiography = 34% reduction; Nomarski method = 18% reduction. Nomarski analysis of affected rod outer segments (ROS) demonstrated optical periodicities (light/dark bands) extending from the base to the tip of the outer segment. Nineteen percent of the cells, however, showed areas where the light/dark bands were not apparent. These homogeneous, "optically silent" regions were interpreted to possibly represent areas where the disc orientation was not perpendicular to the long axis of the ROS.


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B. Zangerl, Q. Sun, J. Pillardy, J. L. Johnson, P. A. Schweitzer, A. G. Hernandez, L. Liu, G. M. Acland, and G. D. Aguirre
Development and characterization of a normalized canine retinal cDNA library for genomic and expression studies.
Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2632 - 2638.
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Copyright © 1987 by the Association for Research in Vision and Ophthalmology