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Investigative Ophthalmology & Visual Science, Vol 28, 1092-1099, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Chemotaxis of rat retinal glia to growth factors found in repairing wounds

AK Harvey, F Roberge and LM Hjelmeland

Retinal glia migrate to sites in the vitreous body and on the inner and outer surfaces of the retina during a wide variety of pathological processes. Using in vitro cultures of rat retinal glia, we have evaluated an extensive list of homogeneous, well-characterized growth factors as chemoattractants for these cells. Humoral growth factors, fibroblast growth factors, extracellular matrix proteins and immune system cytokines all were without activity except for the platelet- derived growth factor (PDGF). Extracts of bovine ocular tissues including vitreous body and retina yielded significant activity.


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