IOVS Journal of General Physiology
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Investigative Ophthalmology & Visual Science, Vol 28, 1195-1199, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Immunopathology of acute experimental histoplasmic choroiditis in the primate

A Anderson, C Taylor, S Azen, JV Jester, C Hagerty, LD Ormerod and RE Smith

The immunopathologic features of experimental acute histoplasmic choroiditis were studied in the nonhuman primate. Using an indirect immunoperoxidase technique, a panel of hybridoma-derived anti-human monoclonal antibodies, recognizing distinct lymphoid cell and macrophage surface antigens, have been adapted for use in the primate system. Twenty-two individual foci of histoplasmic choroiditis from five eyes were studied at time periods from 20 to 60 days post intracarotid injection of yeast phase Histoplasma capsulatum. A mononuclear and granulocytic cell infiltration was seen in all lesions. The predominant cell type was the CAPPEL+ T lymphocyte (suppressor/cytotoxic subset). Other cell types found in smaller numbers were OKT4+ T cells (helper/inducer subset), OK7+ (peripheral B lymphocytes), IgD+ (mantle B cells) and OKM1+ cells (macrophages and polymorphonuclear leukocytes). Herein, we present immunopathologic data on the acute phase of experimental ocular histoplasmosis.




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Copyright © 1987 by the Association for Research in Vision and Ophthalmology