IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pepose, J. S.
Right arrow Articles by Whittum-Hudson, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pepose, J. S.
Right arrow Articles by Whittum-Hudson, J. A.

Investigative Ophthalmology & Visual Science, Vol 28, 1549-1552, Copyright © 1987 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

An immunogenetic analysis of resistance to herpes simplex virus retinitis in inbred strains of mice

JS Pepose and JA Whittum-Hudson

Specific inbred strains of mice have been shown to vary considerably in their resistance and susceptibility to herpes simplex virus (HSV) infection. We injected 2 X 10(5) plaque forming units (PFU) of the KOS strain of HSV-1 intracamerally into one eye of BALB/c, C57Bl/6, and F1 (BALB/c X C57Bl/6) mice. HSV-1 antigens were localized in frozen sections of enucleated eyes at 10 to 14 days post-inoculation. Injected eyes of BALB/c mice showed an anterior uveitis with HSV-1 antigens in the anterior segment and an intact retina free of HSV antigens. The retina of the contralateral uninjected eye was necrotic and contained HSV-1 antigens. In both C57Bl/6 and F1 mice, HSV antigens were limited to anterior segment structures in the injected eye, whereas, in contrast to BALB/c mice, the contralateral retina appeared histologically normal and contained no viral antigens. The C57Bl/6 and F1 strains remained relatively resistant to retinal infection even if pretreated with up to 800 Rads of irradiation. The retinas of normal or sublethally irradiated C57Bl/6 and F1, but not BALB/c strains, were also resistant to intravitreal injection of HSV. These results suggest that resistance to HSV retinitis is a dominantly inherited trait, which depends only partly upon immunologic factors and may be heavily influenced by the inherent ability of host cells from different murine strains to support a productive viral infection.


This article has been cited by other articles:


Home page
 J. Virol.Home page
W. P. Halford, J. W. Balliet, and B. M. Gebhardt
Re-Evaluating Natural Resistance to Herpes Simplex Virus Type 1
J. Virol., September 15, 2004; 78(18): 10086 - 10095.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
K. Norose, A. Yano, X.-M. Zhang, E. Blankenhorn, and E. Heber-Katz
Mapping of Genes Involved in Murine Herpes Simplex Virus Keratitis: Identification of Genes and Their Modifiers
J. Virol., March 7, 2002; 76(7): 3502 - 3510.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
M. Labetoulle, P. Kucera, G. Ugolini, F. Lafay, E. Frau, H. Offret, and A. Flamand
Neuronal pathways for the propagation of herpes simplex virus type 1 from one retina to the other in a murine model
J. Gen. Virol., May 1, 2000; 81(5): 1201 - 1210.
[Abstract] [Full Text]

Home page
 Br. J. Ophthalmol.Home page
H. Ghiasi, S. Cai, G.-C. Perng, A. B Nesburn, and S. L Wechsler
Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring
Br. J. Ophthalmol., April 1, 2000; 84(4): 408 - 412.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1987 by the Association for Research in Vision and Ophthalmology