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Investigative Ophthalmology & Visual Science, Vol 29, 108-111, Copyright © 1988 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Presence of Langerhans cells in the cornea of Klebsiella keratoconjunctivitis mice

E Garcia-Olivares, B Carreras and JM Gallardo
Department of Physiology and Biochemistry, Faculty of Medicine, Granada, Spain.

Frozen sections of normal Balb/c corneas and corneas from Balb/c mice with Klebsiella keratoconjunctivitis were examined for the expression of class I, class II H-2 antigens and MAC-1 antigens using monoclonal antibodies in an immunoperoxidase technique. Class I antigens were readily detected, in both normal and diseased corneas, mainly in the epithelium. Class II (Ia) and MAC-1 antigens were not detected in the normal corneas. However, these two antigens were found mainly in the epithelium and to a lesser extent in the stroma of corneas from keratoconjunctivitis mice. Both normal and diseased corneas were furthermore shown to be peroxidase-. Since Langerhans cells (LC) are Ia+, MAC-1+, and peroxidase- cells, we conclude that although the normal mouse cornea is devoid of these cells, under bacterial infection LC infiltrate the corneal epithelium.


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P. Hamrah, Q. Zhang, Y. Liu, and M. R. Dana
Novel Characterization of MHC Class II-Negative Population of Resident Corneal Langerhans Cell-Type Dendritic Cells
Invest. Ophthalmol. Vis. Sci., March 1, 2002; 43(3): 639 - 646.
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