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Investigative Ophthalmology & Visual Science, Vol 29, 112-118, Copyright © 1988 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The effects of D-penicillamine and daunorubicin on conjunctival fibroblast proliferation and collagen synthesis

LJ McGuigan, HA Quigley, G Lutty, C Enger and E Young
Glaucoma Service, Wilmer Institute, Johns Hopkins Hospital, Baltimore, MD 21205.

Two drugs, D-penicillamine and daunorubicin, were tested for their effect on proliferation and collagen synthesis of cultured conjunctival fibroblasts. This cell type is likely responsible for scar formation and ultimate filter surgery failure in glaucoma patients. Both drugs were antiproliferative; however, D-penicillamine required 2000 times the concentration of daunorubicin to achieve a similar degree of inhibition. D-penicillamine had a more consistent effect on intracellular collagen synthesis than daunorubicin at the doses tested. In contrast, at concentrations of daunorubicin where all proliferation ceased, intracellular production and extracellular transport of collagen were maintained.


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