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Investigative Ophthalmology & Visual Science, Vol 29, 149-152, Copyright © 1988 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Regional distribution of glutathione peroxidase and Glutathione-S- transferase in adult and premature human retinas

MI Naash, JC Nielsen and RE Anderson
Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030.

The activities of glutathione peroxidase (GSH-Px) and glutathione-S- transferase (GSH-S-tase) were investigated in adult and premature human retinas. The measurements were done in the vascular and avascular regions of premature retinas at gestational age of 22-33 weeks and in the central, mid-peripheral, and far peripheral regions of mature retinas from the age of 1 month to 73 years. Among the premature infants, those who survived for greater than 24 hours were supplemented with alpha-tocopherol (vitamin E) on a periodic basis. The vascular and avascular regions of premature retinas had higher activities of GSH-Px when compared to the central and far peripheral regions of mature retinas. Infants surviving more than 24 hr had higher activities of GSH- S-tase in the avascular region than infants who survived less than 24 hr. Survival did not affect either enzyme activity in the vascular regions. Mature retinas showed a decrease in GSH-Px specific activity with age, but no age-related changes in GSH-S-tase were observed. These data demonstrate that premature infants are born with relatively high levels of GSH-Px and GSH-S-tase.


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Copyright © 1988 by the Association for Research in Vision and Ophthalmology