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Investigative Ophthalmology & Visual Science, Vol 29, 1469-1473, Copyright © 1988 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The immediate effect of phenylephrine on aqueous flow in man

MM van Genderen, JA van Best and JA Oosterhuis
Department of Ophthalmology, University Hospital, Leiden, The Netherlands.

Aqueous flow in normal human eyes was assessed at 1 hr intervals via fluorophotometric measurements, starting 4 hr after fluorescein instillation. The average coefficients of variation of the individual flow values were 5.3% and 8.4% for 1 hr and 1 week intervals, respectively. Aqueous flow was measured in 11 healthy volunteers after the instillation of phenylephrine. In the first hour the aqueous flow showed a significant increase: 131% +/- 72% (P less than 0.001) and in the second hour: 121% +/- 92% (P less than 0.002). Between 2 and 5 hr the average flow did not differ significantly from the flow in the untreated fellow eye. There was no marked effect of pupil dilation on aqueous flow.




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Copyright © 1988 by the Association for Research in Vision and Ophthalmology