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Investigative Ophthalmology & Visual Science, Vol 29, 194-199, Copyright © 1988 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

The effect of sodium hyaluronate on the corneal epithelium. An ultrastructural study

YS Wysenbeek, N Loya, I Ben Sira, I Ophir and Y Ben Shaul
Department of Ophthalmology, Beilinson Medical Center, Petah Tikva, Israel.

The effect of sodium hyaluronate (NaHa) 1% and 0.1% was studied on 14- day chick embryo corneal epithelium by scanning electron microscopy. It was found that NaHa 1% or 0.1% had no toxic effects on the chick corneal epithelium and the normal architecture of the cells and the morphology of the microvilli was well preserved. A combination of NaHa 0.1% and benzalkonium chloride (BAK) 0.01% reduced the toxic effect of BAK on the surface corneal epithelium. NaHa 0.1% provided a better protection of the corneal epithelium against dryness than hydroxyethylcellulose (HEC) 0.1% or phosphate buffer saline (PBS).


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