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(Investigative Ophthalmology and Visual Science. 1964;3:366-373.)
© 1964 by The Association for Research in Vision and Ophthalmology, Inc.

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Gamma Globulin in Experimental Herpes Simplex Keratitis

ARMSTEAD B. HUDNELL 1 and SUYDUM OSTERHOUT 1

1 Division of Ophthalmology, Bowman Cray School of Medicine, Wake Forest College, Winston-Salem, N. C., Department of Medicine and Division of Ophthalmology, Duke University School of Medicine, Durham, N. C.

The chronic keratitis resulting from the steroid treatment of acute herpes simplex infection of the rabbit cornea was significantly improved by the subconjunctival administration of either human or rabbit gamma globulin, the latter possessing no neutralizing antibody to herpes simplex virus. Virus titrations of this late lesion were consistently negative. The etiological and therapeutic implications of these observations will be discussed. It is suggested they provide additional support to the concept that this chronic inflammatory disease is not related to a continuing virus infection.






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