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(Investigative Ophthalmology and Visual Science. 1964;3:577-584.)
© 1964 by The Association for Research in Vision and Ophthalmology, Inc.

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Hydration of the Lens During the Development of Galactose Cataract

JIN H. KINOSHITA 1 and LORENZO O. MEROLA 1

1 Howe Laboratory of Ophthalmology, Harvard Medical School, and the Massachusetts Eye and Ear Infirmary, Boston, Mass.

Changes in hydration of the lens which occur in three arbitrarily defined stages during the development of galactose cataract have been studied. At the onset of the cataractous process the increase in hydration is due to the accumulation of dulcitol. The water content which is only slightly increased in the intermediate stage is accounted for mainly by the retention dulcitol, and to a smaller degree by an increase in salt. In contrast to the early stages, when the cataract matures the large influx of water is no longer attributed to the accumulation of dulcitol but to an increase in NaCl.






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