IOVS AJP: Endocrinology and Metabolism
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(Investigative Ophthalmology and Visual Science. 1964;3:601-605.)
© 1964 by The Association for Research in Vision and Ophthalmology, Inc.

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Catechol-O-methyl Transferase and Monoamine Oxidase Activity in the Ocular Tissues of Albino Rabbits

STEPHEN WALTMAN 1 and MARVIN SEARS 1

1 Section of Ophthalology, Department of Surgery, Yale University School of Medicine, New Haven, Conn.

The distribution of catechol-O-methyl transferase and monoamine oxidase activity in the ocular tissues of albino rabbits has been determined with a radioactive tracer assay. The distribution of the former varied in the different tissues within a restricted range whereas the distribution of monoamine oxidase activity exhibited larger variations. Sympathetic denervation did not appear to affect catechol-O-methyl transferase levels although moderate decreases in MAO levels were observedone week after denervation. The possible role of these enzymes for catecholamine metabolism in the eye is briefly discussed.






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