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Investigative Ophthalmology & Visual Science, Vol 34, 3090-3095, Copyright © 1993 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Levodopa/carbidopa for childhood amblyopia

LE Leguire, GL Rogers, DL Bremer, PD Walson and ML McGregor
Department of Ophthalmology, Children's Hospital, Columbus, Ohio 43205.

PURPOSE. To evaluate the efficacy and tolerance of two low doses of levodopa/carbidopa (25/6.25 mg, 50/12.5 mg) and placebo (Tums) in 20 children with amblyopia between the ages of 4 and 14 years. METHODS. A double-masked placebo-controlled randomized 8-hour study was performed during which subjects received one of two doses of levodopa/carbidopa or placebo, combined with occlusion of the dominant eye. Visual acuity was measured at baseline and at 1 and 5 hours after capsule ingestion. Tolerance was assessed by questionnaire and physical examination. RESULTS. Visual acuity significantly improved by one line, from an overall average of 20/121 to 20/96, in the amblyopic eyes of both groups that received levodopa/carbidopa. Visual acuity did not significantly change in the placebo group. Tolerance was similar among all three groups. CONCLUSION. Average dose levels of 0.95/0.24 mg/kg and 1.94/0.49 mg/kg of levodopa/carbidopa were found to be well tolerated and efficacious at temporarily improving visual acuity in amblyopic eyes of children.




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Copyright © 1993 by the Association for Research in Vision and Ophthalmology