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Investigative Ophthalmology & Visual Science, Vol 34, 3154-3160, Copyright © 1993 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Expression of glial fibrillary acidic protein in rabbit Muller cells after lensectomy-vitrectomy

A Yoshida, S Ishiguro and M Tamai
Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.

PURPOSE. To assess retinal response after lensectomy-vitrectomy, the authors analyzed glial fibrillary acidic protein (GFAP), which retinal glial cells express in several pathologic conditions. METHODS. GFAP expression was examined by means of immunohistochemistry, Western blot analysis, and enzyme-linked immunosorbent assay (ELISA) in rabbit retina after lensectomy-vitrectomy. RESULTS. Muller cells had detectable GFAP immunoreactivity in peripheral retina 3 days after surgery. GFAP immunoreactivity was present in both peripheral and posterior regions 7 days, 14 days, and 6 months after surgery. The authors confirmed that anti-GFAP antibody recognized the 51 kDa protein specifically by Western blot analysis. Time-dependent increase of GFAP in peripheral retina was also obtained by ELISA. CONCLUSIONS. Such progressive GFAP accumulation in Muller cells, which are sensitive to microenvironmental changes, may reflect some underlying retinal response after lensectomy-vitrectomy.


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