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Investigative Ophthalmology & Visual Science, Vol 34, 2124-2129, Copyright © 1993 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Lens regeneration in New Zealand albino rabbits after endocapsular cataract extraction

A Gwon, L Gruber, C Mantras and C Cunanan
Allergen Pharmaceutical, Irvine, CA 92713-9534.

PURPOSE. To evaluate the regenerative capacity of the adult rabbit lens after removal of a Concanavalin A-induced posterior subcapsular cataract. METHODS. Cataractogenesis was induced by intravitreal injection of Concanavalin A in adult New Zealand albino rabbits. At 7 mo postinjection, the cataracts were removed. Endocapsular lens extraction was performed by phacoemulsification and irrigation/aspiration with Balanced Salt Solution. RESULTS. Postoperatively, lens regeneration was first noted in the Balanced Salt Solution normal lens group at 3 weeks and the Concanavalin A cataract group at 6 weeks. By the 3-mo postoperative examination, lens regrowth, measured by digital image analysis, filled 74.5% of the capsule bag in the Balanced Salt Solution normal lens group and 46.6% in the Concanavalin A cataract group. In the latter group, less lens material was regenerated and at a slower rate than in eyes with extraction of a normal lens. CONCLUSION. This experimental model is the first to show that lens regeneration can occur after removal of cataracts secondary to inflammation.


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W. Guo, F. Shang, Q. Liu, L. Urim, M. Zhang, and A. Taylor
Ubiquitin-proteasome pathway function is required for lens cell proliferation and differentiation.
Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2569 - 2575.
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