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Investigative Ophthalmology & Visual Science, Vol 34, 2138-2141, Copyright © 1993 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Senile cataract progression studies using the Lens Opacities Classification System II

BV Magno, MB Datiles 3d and SM Lasa
Ophthalmic Genetics and Clinical Services Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.

PURPOSE. To determine cataract progression rates at 6-mo intervals as evaluated using the Lens Opacities Classification System II (LOCS II). METHODS. Idiopathic age-related cataracts in both eyes of 50 cataract patients and 17 normal control subjects were graded. The lenses were reexamined at 6 and 12 mo (+/- 2 mo) from baseline to determine rates of change. Progression or regression in patients or control subjects was considered to have occurred at the 6-mo examination if a one or more step change in the LOCS II grading was noted in at least one eye at 6 mo and maintained at the 12-mo visit. RESULTS. Six months from baseline, 38% of patients' conditions worsened in the nuclear area, 34% of patients' conditions worsened in the cortical region, and 8% of patients' conditions worsened in the posterior subcapsular region. Regression rates were 4% in each region. The percentages of patients progressing in the nuclear and cortical regions were significantly greater than the corresponding regression rates (P < .001). Greater progression was noted in the nuclear (P = .06) and posterior subcapsular (P < .01) regions in patients with early opacities (LOCS + 1/+2) as compared to patients with no opacities initially in the same lenticular areas. CONCLUSION. This study suggests that the LOCS II is capable of detecting changes in lens opacities in a relatively short period of time among persons with early to moderate opacities.


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