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Investigative Ophthalmology & Visual Science, Vol 34, 2141-2145, Copyright © 1993 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Retinal pigment epithelial cell transplants in retinal degeneration slow mice do not rescue photoreceptor cells

L Li, HJ Sheedlo and JE Turner
Department of Neurobiology and Anatomy, Wake Forest University, Winston- Salem, North Carolina.

PURPOSE. To determine if retinal pigment epithelial cells are in any way involved in the degeneration of photoreceptor cells in the retinal dystrophy mouse model, retinal degeneration slow (rds); to determine if normal retinal pigment epithelial cell transplants can affect outer segment development in the retina. METHODS. Retinal pigment epithelial cells of neonatal normal pigmented C3H mice were isolated and transplanted into retinas of postnatal day 33 albino rds mice. Then eyes of 4-month-old rds mice, retinal pigment epithelial cell- transplanted and sham and non-treated control mice, were processed for light and electron microscopy and the thickness of the outer nuclear layer were measured and compared. RESULTS. Measurements of outer nuclear layer thickness in the transplant and control groups revealed that normal retinal pigment epithelial cell transplants did not cause photoreceptor cell rescue in rds mice. In addition, outer segments were not seen in retinal pigment epithelial cell-transplanted rds retinas. CONCLUSIONS. This study supports the conclusions of other investigators that the photoreceptor cell is the primary site of the genetic defect that results in retinal dystrophy in the rds mouse model.


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G. Woch, R. B. Aramant, M. J. Seiler, B. T. Sagdullaev, and M. A. McCall
Retinal Transplants Restore Visually Evoked Responses in Rats with Photoreceptor Degeneration
Invest. Ophthalmol. Vis. Sci., June 1, 2001; 42(7): 1669 - 1676.
[Abstract] [Full Text]


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