IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seko, Y.
Right arrow Articles by Tokoro, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seko, Y.
Right arrow Articles by Tokoro, T.

Investigative Ophthalmology & Visual Science, Vol 36, 1183-1187, Copyright © 1995 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Expression of bFGF and TGF-beta 2 in experimental myopia in chicks

Y Seko, H Shimokawa and T Tokoro
Department of Ophthalmology, Tokyo Medical and Dental University School of Medicine, Japan.

PURPOSE. To determine factors that control ocular enlargement in experimental form-deprivation myopia and to clarify the mechanism of form-deprivation myopia. METHODS. After the left eyes of 20 chicks were monocularly occluded for 2 weeks, protein, basic fibroblast growth factor (bFGF) and transforming growth factor (TGF)-beta 2 contents in samples of constant area (circular button, diameter = 8.5 mm) in the retina-retinal pigment epithelium (RPE)-choroid and the sclera in the posterior region of control and myopic eyes were determined by enzyme- linked immunosorbent assay. RESULTS. The bFGF content (per circular button) and bFGF concentration (per mg protein) were significantly lower in the sclera in the posterior region of the myopic eyes than in control eyes. The bFGF content and concentration were similar in the retina-RPE-choroid in myopic and control eyes. The TGF-beta 2 content and concentration were significantly higher in myopic eyes in both the retina-RPE-choroid and the sclera (P < 0.05). CONCLUSIONS. These results are consistent with the possibility that bFGF and TGF-beta 2 regulate ocular enlargement or respond to myopiagenic mechanisms in form-deprivation myopia.


This article has been cited by other articles:


Home page
 IOVSHome page
K. K. Pertile, M. Schache, F. M. A. Islam, C. Y. Chen, M. Dirani, P. Mitchell, and P. N. Baird
Assessment of TGIF as a Candidate Gene for Myopia
Invest. Ophthalmol. Vis. Sci., January 1, 2008; 49(1): 49 - 54.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. I. Jobling, M. Nguyen, A. Gentle, and N. A. McBrien
Isoform-specific Changes in Scleral Transforming Growth Factor-{beta} Expression and the Regulation of Collagen Synthesis during Myopia Progression
J. Biol. Chem., April 30, 2004; 279(18): 18121 - 18126.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
S-M Saw, L Tong, K-S Chia, D Koh, Y-S Lee, J Katz, and D T H Tan
The relation between birth size and the results of refractive error and biometry measurements in children
Br. J. Ophthalmol., April 1, 2004; 88(4): 538 - 542.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. A. Rada, C. A. Perry, M. L. Slover, and V. R. Achen
Gelatinase A and TIMP-2 Expression in the Fibrous Sclera of Myopic and Recovering Chick Eyes
Invest. Ophthalmol. Vis. Sci., December 1, 1999; 40(13): 3091 - 3099.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by the Association for Research in Vision and Ophthalmology