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Investigative Ophthalmology & Visual Science, Vol 36, 1732-1737, Copyright © 1995 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Effects of ornithine on the electroretinogram in cat retina

K Hiroi, F Yamamoto and Y Honda
Department of Ophthalmology, Faculty of Medicine, Kyoto University, Japan.

PURPOSE. To study the acute effects of L-ornithine hydrochloride on the function of cat retina in vivo. METHODS. A small amount of ornithine was administered intravitreously or intravenously. Changes in retinal function were monitored by vitreal electroretinogram (ERG) and intraretinal ERG with K(+)-selective microelectrodes. RESULTS. Intravitreal injections (0.2 to 0.5 M; 15 microliters) of ornithine caused a decrease in the standing potential and the vitreal ERG c-wave amplitude. The ERG c-wave decreased continuously during a 5-hour period. Intravenous injection (0.2 M; 10 ml) of ornithine also diminished the c-wave. Intraretinal recording showed that the amplitudes of the retinal pigment epithelium (RPE) component and the Muller cell component of the ERG c-wave were reduced after intravitreal injection. The light-evoked [K+]o decrease in the subretinal space did not change. The change in transepithelial resistance contributed little to the decrease in the c-wave. CONCLUSION. These results demonstrated that ornithine selectively affects the c-wave and suggested that it affects RPE and Muller cells directly without affecting photoreceptors.


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