IOVS Biophysical Journal
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ma, D.
Right arrow Articles by Niederkorn, J. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ma, D.
Right arrow Articles by Niederkorn, J. Y.

Investigative Ophthalmology & Visual Science, Vol 37, 2293-2301, Copyright © 1996 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Association between NM23-H1 gene expression and metastasis of human uveal melanoma in an animal model

D Ma, GP Luyten, TM Luider, MJ Jager and JY Niederkorn
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75235-9057, USA.

PURPOSE: To evaluate the role of nm23 gene expression in the development of metastases of human uveal melanomas in an animal model. METHODS: Seven human uveal melanoma cell lines and two murine skin melanoma cell lines were subjected to Northern blot analysis for the detection of nm23-H1 mRNA and to immuno-histochemistry to detect nm23 antigen. Each tumor cell line was transplanted intracamerally into nude mice, and the metastatic behavior was evaluated by histopathologic analysis of the livers and by determining host survival times. RESULTS: There was a strong inverse correlation between the levels of nm23 mRNA expression and nm23 antigen expression and the development of metastases of all seven human uveal melanomas and both murine skin melanomas transplanted intracamerally. Host survival time also was correlated with the degree of nm23 gene expression. CONCLUSIONS: The expression of nm23 mRNA and nm23 antigen in human uveal melanomas is correlated closely with reduced metastatic behavior in experimental animals and may serve as a sensitive prognostic indicator of malignancy and survival in patients with uveal melanomas.


This article has been cited by other articles:


Home page
 Mol. Cell. ProteomicsHome page
G.-J. C. M. van den Bemd, J. Krijgsveld, T. M. Luider, A. L. van Rijswijk, J. A. A. Demmers, and G. Jenster
Mass Spectrometric Identification of Human Prostate Cancer-derived Proteins in Serum of Xenograft-bearing Mice
Mol. Cell. Proteomics, October 1, 2006; 5(10): 1830 - 1839.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the Association for Research in Vision and Ophthalmology