IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kingsley, R. E.
Right arrow Articles by Marfurt, C. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kingsley, R. E.
Right arrow Articles by Marfurt, C. F.

Investigative Ophthalmology & Visual Science, Vol 38, 388-395, Copyright © 1997 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Topical substance P and corneal epithelial wound closure in the rabbit

RE Kingsley and CF Marfurt
Indiana University School of Medicine, South Bend Center for Medical Education, University of Notre Dame, IN 46556, USA.

PURPOSE: The authors determined the effect of topically applied substance P (SP) on the rate of corneal epithelial wound closure in the rabbit. METHODS: Uniform circular lesions, 6.5 mm in diameter, were made bilaterally in the corneal epithelium of 24 rabbits using N- heptanol. Substance P was applied repeatedly to one eye, and the SP1-7 fragment was applied to the contralateral (control) eye until wound closure was obtained. Three concentrations of peptide solution (5 x 10(- 5) M, 5 x 10(-4) M, and 5 x 10(-3) M) were tested in separate groups of eight animals each. An additional eight animals received topical applications (5 x 10(-7) M) of the neurokinin-1 (NK1)-specific SP receptor antagonist CP-99,994-01 or its ineffective enantiomer CP- 100,263-01. The mean rates of wound healing for each group of experimental and control eyes were determined by linear regression and analyzed by analysis of variance. RESULTS: There were no statistically significant differences in the mean rates of wound closure (range, 0.083 to 0.106 mm/hour) between experimental- and control-treated corneas for any of the four groups tested. CONCLUSIONS: The topical application of SP or its NK1 receptor antagonist has no significant effect on the rate of corneal epithelial wound closure in the rabbit.


This article has been cited by other articles:


Home page
 IOVSHome page
T. Bourcier, N. Rondeau, S. Paquet, P. Forgez, A. Lombet, F. Pouzaud, W. Rostene, V. Borderie, and L. Laroche
Expression of Neurotensin Receptors in Human Corneal Keratocytes
Invest. Ophthalmol. Vis. Sci., June 1, 2002; 43(6): 1765 - 1771.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
A. Lambiase, L. Manni, S. Bonini, P. Rama, A. Micera, and L. Aloe
Nerve Growth Factor Promotes Corneal Healing: Structural, Biochemical, and Molecular Analyses of Rat and Human Corneas
Invest. Ophthalmol. Vis. Sci., April 1, 2000; 41(5): 1063 - 1069.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the Association for Research in Vision and Ophthalmology