IOVS Journal of Virology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Solberg, Y.
Right arrow Articles by Belkin, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Solberg, Y.
Right arrow Articles by Belkin, M.

Investigative Ophthalmology & Visual Science, Vol 38, 1380-1389, Copyright © 1997 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

MK-801 has neuroprotective and antiproliferative effects in retinal laser injury

Y Solberg, M Rosner, J Turetz and M Belkin
Goldschleger Eye Research Institute, Sheba Medical Center, Tel-Aviv University, Israel.

PURPOSE: Treatment of the retina by laser photocoagulation often is complicated by an immediate side effect of visual impairment, caused by unavoidable, laser-induced destruction of healthy tissue adjacent to the lesion. A neuroprotective therapy that salvages this healthy tissue might enhance the benefit obtained from the treatment. This study was proposed to determine whether glutamate-receptor blockers can provide adjuvant neuroprotection during laser photocoagulation. The effect of MK-801, an NMDA-receptor antagonist, on laser-induced retinal injury was examined, in a rat model. METHODS: Argon laser lesions were created in the retinas of 36 DA rats, and were followed immediately by intraperitoneal injections of MK-801 (2 mg/kg) or saline. The animals were killed after 3, 20, or 60 days and the retinal lesions were evaluated histologically and morphometrically. RESULTS: Photoreceptor- cell loss was significantly less in MK-801-treated rats than in control animals. The proliferative membrane composed of retinal pigment epithelial cells and neovascular blood vessels, which was seen at the base of the lesion in control group retinas, was smaller in the MK-801- treated retinas. In rats treated with a higher dose of MK-801, the lesions showed almost no proliferative reaction. CONCLUSIONS: A potent noncompetitive NMDA-receptor blocker, MK-801 exhibits neuroprotective and antiproliferative properties in the retina. Glutamate-receptor blockers should be investigated further as potential adjuvant therapy in retinal photocoagulation treatments.


This article has been cited by other articles:


Home page
 IOVSHome page
A. Barak, T. Goldkorn, and L. S. Morse
Laser Induces Apoptosis and Ceramide Production in Human Retinal Pigment Epithelial Cells
Invest. Ophthalmol. Vis. Sci., July 1, 2005; 46(7): 2587 - 2591.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
W.-Y. Shen, K. L Garrett, L. da Cruz, I. J Constable, and P. E Rakoczy
Dynamics of phosphorothioate oligonucleotides in normal and laser photocoagulated retina
Br. J. Ophthalmol., July 1, 1999; 83(7): 852 - 861.
[Abstract] [Full Text]

Home page
 Arch OphthalmolHome page
E. Yoles and M. Schwartz
Elevation of Intraocular Glutamate Levels in Rats With Partial Lesion of the Optic Nerve
Arch Ophthalmol, July 1, 1998; 116(7): 906 - 910.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the Association for Research in Vision and Ophthalmology