IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ueda, H.
Right arrow Articles by Ohno, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ueda, H.
Right arrow Articles by Ohno, S.

Investigative Ophthalmology & Visual Science, Vol 38, 1627-1630, Copyright © 1997 by Association for Research in Vision and Ophthalmology

ARTICLES AND REPORTS

Immunocytochemical study of dystrophin localization in cone cells of mouse retinas

H Ueda, Y Kato, T Baba, N Terada, Y Fujii, S Tsukahara and S Ohno
Department of Anatomy, Yamanashi Medical University, Tamaho, Japan.

PURPOSE: Previously, the authors reported that dystrophin was observed under the rod cell membranes in rat retinas. However, it was not determined whether dystrophin is located in cone cells. In the current study, the authors clarify dystrophin localization in cone cells of mouse retinas. METHODS: Immunoblotting, confocal laser scanning microscopy, and immunoelectron microscopy were used to investigate retinal dystrophin with a monoclonal antibody raised against the human dystrophin C-terminus. RESULTS: Immunoblotting analysis showed some immunoreactive bands from retinal extracts. Confocal images indicated two different immunostaining patterns: One was a tiny dot, and the other was a larger, aggregated dot. Immunoelectron microscopy revealed that retinal dystrophin was localized in cone cells as well as in rod cells. CONCLUSIONS: Retinal dystrophin is a common component of cone and rod cells and probably is related to the physiological function of photoreceptor cells.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
B. A. Allwardt, A. B. Lall, S. E. Brockerhoff, and J. E. Dowling
Synapse Formation Is Arrested in Retinal Photoreceptors of the Zebrafish nrc Mutant
J. Neurosci., April 1, 2001; 21(7): 2330 - 2342.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. Ueda, T. Baba, K. Kashiwagi, H. Iijima, and S. Ohno
Dystrobrevin Localization in Photoreceptor Axon Terminals and at Blood-Ocular Barrier Sites
Invest. Ophthalmol. Vis. Sci., November 1, 2000; 41(12): 3908 - 3914.
[Abstract] [Full Text]

Home page
 J. Histochem. Cytochem.Home page
H. Ueda, T. Gohdo, and S. Ohno
b-Dystroglycan Localization in the Photoreceptor and Muller cells in the Rat Retina Revealed by Immunoelectron Microscopy
J. Histochem. Cytochem., February 1, 1998; 46(2): 185 - 192.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the Association for Research in Vision and Ophthalmology