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(Investigative Ophthalmology and Visual Science. 2000;41:320-324.)
© 2000 by The Association for Research in Vision and Ophthalmology, Inc.

Background Adaptation in Children with a History of Mild Retinopathy of Prematurity

Ronald M. Hansen and Anne B. Fulton

From the Department of Ophthalmology, Children’s Hospital and Harvard Medical School, Boston, Massachusetts.

PURPOSE. In children with a history of mild retinopathy of prematurity (ROP), test the hypothesis that elevation of the parafoveal over peripheral dark-adapted threshold is due to photoreceptor rather than postreceptor dysfunction.

METHODS. A forced choice procedure was used to measure thresholds for detection of 2o diameter, 50 msec, blue stimuli presented 10o (parafoveal) or 30o (peripheral) eccentric in the dark and in the presence of steady red backgrounds (-4 to +2 log scot td). Four ROP and four control subjects were tested at both eccentricities. A model of the increment threshold function was fit to the data to calculate the eigengrau and dark-adapted threshold.

RESULTS. Both ROP subjects with elevated parafoveal thresholds also have elevated parafoveal eigengraus. On the other hand, parafoveal and peripheral eigengraus are equal in ROP subjects without parafoveal threshold elevation. Nevertheless, the dark-adapted thresholds of all ROP subjects are higher than those of any control subject at both sites.

CONCLUSIONS. The parafoveal threshold elevation is due to rod dysfunction. There is also evidence of peripheral rod photoreceptor involvement in the subjects with ROP.




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