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(Investigative Ophthalmology and Visual Science. 2001;42:2043-2048.)
© 2001 by The Association for Research in Vision and Ophthalmology, Inc.

Scleral Plug of Biodegradable Polymers Containing Ganciclovir for Experimental Cytomegalovirus Retinitis

Eiji Sakurai1, Yoshito Matsuda1, Hironori Ozeki1, Noriyuki Kunou1, Katsuhisa Nakajima2 and Yuichiro Ogura1

1 From the Departments of Ophthalmology and 2 Virology, Nagoya City University Medical School, Japan.

PURPOSE. To evaluate the efficacy of a biodegradable scleral plug containing ganciclovir (GCV) in a rabbit model of human cytomegalovirus (HCMV) retinitis.

METHODS. To develop a rabbit model for HCMV retinitis, HCMV solution was injected once into the vitreous cavity of pigmented rabbits. The treated animals were divided into three groups: group A received no treatment, group B was treated once with GCV solution, and group C was treated with a scleral plug containing GCV. Rabbits in group B received an intravitreal injection of GCV solution 1 week after HCMV inoculation. In group C, the scleral plug containing GCV was implanted in the vitreous of the rabbits 1 week after HCMV inoculation. Ophthalmoscopically, vitreoretinal findings in each group were graded from 0+ to 4+ every week for 4 weeks after HCMV injection.

RESULTS. Eyes of group A rabbits showed whitish retinal exudates and vitreous opacities 3 days after HCMV inoculation. These materials increased gradually until 3 weeks after HCMV inoculation. Scores for vitreoretinal lesions were significantly lower in eyes of group B rabbits compared with those of group A at 1 week after GCV injection (P < 0.05). However, vitreoretinal inflammation in eyes of group B rabbits increased again thereafter, and no significant difference in inflammation between groups A and B was found 2 weeks after GCV injection. In eyes of group C, scores for vitreoretinal lesions were significantly lower compared with those in both group A and group B at 3 weeks after HCMV inoculation (P < 0.01).

CONCLUSIONS. The results demonstrated that sustained release of GCV into the vitreous cavity with biodegradable scleral plugs was effective for the treatment of experimentally induced HCMV retinitis in rabbits.




eLetters:

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Animal Paradigm of Human Cytomegalovirus Retinitis
Yasutaka Ando
IOVS Online, 22 Apr 2002 [Full text]
Author Response: Animal Paradigm of Human Cytomegalovirus Retinitis
Yuichiro Ogura
IOVS Online, 22 Apr 2002 [Full text]

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