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(Investigative Ophthalmology and Visual Science. 2006;47:3683-3689.)
© 2006 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.05-1284
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Retinal Oxygenation and Oxygen Metabolism in Abyssinian Cats with a Hereditary Retinal Degeneration

Lissa Padnick-Silver,1,2 Jennifer J. Kang Derwent,1,3 Elizabeth Giuliano,4 Kristina Narfström,4,5 and Robert A. Linsenmeier1,6

1From the Departments of Biomedical Engineering and 6Neurobiology and Physiology, Northwestern University, Evanston, Illinois; the 2Division of Ophthalmology, Evanston Northwestern Healthcare, Glenview, Illinois; the 3Department of Biomedical Engineering and Pritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology, Chicago, Illinois; and the 4Department of Medicine and Surgery, College of Veterinary Medicine, and the 5Department of Ophthalmology, Mason Eye Institute, University of Missouri, Columbia, Missouri.

PURPOSE. To investigate the effects of a hereditary retinal degeneration on retinal oxygenation and determine whether it is responsible for the severe attenuation of retinal circulation in hereditary photoreceptor degenerations.

METHODS. Seven adult Abyssinian cats affected by hereditary retinal degeneration were studied. Oxygen microelectrodes were used to collect spatial profiles of retinal oxygenation in anesthetized animals. A one-dimensional model of oxygen diffusion was fitted to the data to quantify photoreceptor oxygen utilization (QO2).

RESULTS. Photoreceptor QO2 progressively decreased until it reached zero in the end stage of the disease. Average inner retinal oxygen tension remained within normal limits at all disease stages, despite the observed progressive retinal vessel attenuation. Light affected photoreceptors normally, decreasing QO2 by ~50% at all stages of the disease.

CONCLUSIONS. Loss of photoreceptor metabolism allows choroidal oxygen to reach the inner retina, attenuating the retinal circulation in this animal model of retinitis pigmentosa (RP) and probably also in human RP. As the degeneration progresses, there is a strong relationship between changes in the a-wave of the ERG and changes in rod oxidative metabolism, indicating that these two functional measures change together.




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Copyright © 2006 by the Association for Research in Vision and Ophthalmology